EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity
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چکیده
منابع مشابه
EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.
EGFR and its constitutively activated variant EGFRvIII are linked to glioblastoma resistance to therapy, the mechanisms underlying this association, however, are still unclear. We report that in glioblastoma, EGFR/EGFRvIII paradoxically co-expresses with p53-upregulated modulator of apoptosis (PUMA), a proapoptotic member of the Bcl-2 family of proteins primarily located on the mitochondria. EG...
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From the Laboratory of Genomic Diversity, National Cancer Institute, Frederick Cancer Research and De velopment Center, Frederick, MD 21702-1201. We are grateful to acknowledge lull collaborative credit to the investigators listed in Figure lA who supplied biologi cal specimens upon which this study is based. We would like to thank all the collaborators that collected or aided in the collecti...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2010
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2010.01.028